Publications 2000-Present

Vereide D, Sugden B.
Proof for EBV's sustaining role in Burkitt's lymphomas.
Semin Cancer Biol. 2009 Jul 21. [Epub ahead of print]

Pratt ZL, Kuzembayeva M, Sengupta S, Sugden B.
The microRNAs of Epstein-Barr Virus are expressed at dramatically differing levels among cell lines.
Virology. 2009 Apr 10;386(2):387-97. Epub 2009 Feb 12.

Dresang LR, Vereide DT, Sugden B.
Identifying sites bound by Epstein-Barr virus nuclear antigen 1 (EBNA1) in the human genome: defining a position-weighted matrix to predict sites bound by EBNA1 in viral genomes.
J Virol. 2009 Apr;83(7):2930-40. Epub 2009 Jan 7.

Lee DY, Lee J, Sugden B.
The unfolded protein response and autophagy: herpesviruses rule!
J Virol. 2009 Feb;83(3):1168-72. Epub 2008 Sep 10.

Mack AA, Sugden B.
EBV is necessary for proliferation of dually infected primary effusion lymphoma cells.
Cancer Res. 2008 Sep 1;68(17):6963-8.

Wang CY, Sugden B.
Identifying a property of origins of DNA synthesis required to support plasmids stably in human cells.
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9639-44. Epub 2008 Jul 8.

Sengupta S, den Boon JA, Chen IH, Newton MA, Stanhope SA, Cheng YJ, Chen CJ, Hildesheim A, Sugden B, Ahlquist P.
MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins.
Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5874-8. Epub 2008 Apr 4.

Lindner SE, Zeller K, Schepers A, Sugden B.
The affinity of EBNA1 for its origin of DNA synthesis is a determinant of the origin's replicative efficiency.
J Virol. 2008 Jun;82(12):5693-702. Epub 2008 Apr 2.

Lee DY, Sugden B.
The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis.
Blood. 2008 Feb 15;111(4):2280-9. Epub 2007 Nov 27.

Lee DY, Sugden B.
The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy.
Oncogene. 2008 May 1;27(20):2833-42. Epub 2007 Nov 26.

Nanbo A, Sugden A, Sugden B.
The Coupling of Synthesis and Partitioning of EBV's Plasmid Replicon Is Revealed in Live Cells.
EMBO J. 2007 Oct 3;26(19):4252-62. Epub 2007 Sep 13.
*The program referenced in this paper can be downloaded here: Plasmid Code Document.
*A brief set-up description can also be downloaded here: Read Me Document.

Lee J, Sugden B.
A Membrane Leucine Heptad Contributes to LMP1's Trafficking, Signaling and Transformation.
J Virol. 2007 Sep;81(17):9121-30. Epub 2007 Jun 20.

Lindner SE, Sugden B.
The plasmid replicon of Epstein-Barr virus: Mechanistic insights into efficient, licensed, extrachromosomal replication in human cells.
Plasmid. 2007 Jul;58(1):1-12. Epub 2007 Mar 9.

Altmann M, Dagmar P, Romana R, Wang J, Sugden B, Wolfgang H.
Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes.
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14188-93. Epub 2006 Sep 11.

Wolfgang H, Sugden B.
M. DePamphilis (Ed.)
Epstein-Barr Virus.
DNA Replication and Human Disease, Chap. 34. Cold Spring Harbor Laboratory: Cold Spring Harbor Press. (2006).

Sengupta S, den Boon JA, Chen IH, Newton MA, Dahl DB, Chen M, Cheng YJ, Westra WH, Chen CJ, Hildesheim A, Sugden B, Ahlquist P.
Genome-Wide Expression Profiling Reveals EBV-Associated Inhibition of MHC Class I Expression in Nasopharyngeal Carcinoma.
Cancer Res. 2006 Aug 15;66(16):7999-8006.

Sugden B.
Virology: micro mystery solution
Nature. 2006 Jul 6;442(7098):33-4.

Wang J, Lindner SE, Leight ER, Sugden B.
Essential elements of a licensed, mammalian plasmid origin of DNA synthesis.
Mol Cell Biol. 2006 Feb;26(3):1124-34.

Perrigoue JG, den Boon JA, Friedl A, Newton MA, Ahlquist P, Sugden B.
Lack of association between EBV and breast carcinoma.
Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):809-14.

Mack AA, Sugden B.
E. S. Robertson (Ed.)
The Plasmid Replicon of EBV: an Element That Underlies EBV's Transforming Functions.
Infection, Pathogenesis, Molcular Biology, and Control of Epstin-Barr Virus. Horizon Press. (2005):379-402.

Dirmeier U, Hoffmann R, Kilger E, Schultheiss U, Briseno C, Gires O, Kieser A, Eick D, Sugden B, Hammerschmidt W.
Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis.
Oncogene. 2005 Mar 3;24(10):1711-7.

Wang J, Sugden B.
Origins of bidirectional replication of Epstein-Barr virus: models for understanding mammalian origins of DNA synthesis.
J Cell Biochem. 2005 Feb 1;94(2):247-56.

Hammerschmidt W, Sugden B.
Epstein-Barr virus sustains Burkitt's lymphomas and Hodgkin's disease.
Trends Mol Med. 2004 Jul;10(7):331-6.

Lam N, Sandberg ML, Sugden B.
High physiological levels of LMP1 result in phosphorylation of eIF2 alpha in Epstein-Barr virus-infected cells.
J Virol. 2004 Feb;78(4):1657-64.

Wang CY, Sugden B.
New viruses shake old paradigms.
J Clin Invest. 2004 Jan;113(1):21-3.

Kennedy G, Komano J, Sugden B.
Epstein-Barr virus provides a survival factor to Burkitt's lymphomas.
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14269-74. Epub 2003 Nov 5.

Kennedy G, Sugden B.
EBNA-1, a bifunctional transcriptional activator.
Mol Cell Biol. 2003 Oct;23(19):6901-8.

Lam N, Sugden B.
LMP1, a viral relative of the TNF receptor family, signals principally from intracellular compartments.
EMBO J. 2003 Jun 16;22(12):3027-38.

Lam N, Sugden B.
CD40 and its viral mimic, LMP1: similar means to different ends.
Cell Signal. 2003 Jan;15(1):9-16.

Kaykas A, Worringer K, Sugden B.
LMP-1's transmembrane domains encode multiple functions required for LMP-1's efficient signaling.
J Virol. 2002 Nov;76(22):11551-60.

Sugden B, Takada K.
Epstein-Barr virus and human cancer: Hokkaido University, July 4-6, 2001.
Jpn J Cancer Res. 2001 Dec;92(12):1352-4.

Sugden B.
In the beginning: a viral origin exploits the cell.
Trends Biochem Sci. 2002 Jan;27(1):1-3. Review.

Sugden B.
Howard M. Temin: December 10, 1934-February 9, 1994.
Biogr Mem Natl Acad Sci. 2001;79:336-74.

Leight ER, Sugden B.
The cis-acting family of repeats can inhibit as well as stimulate establishment of an oriP replicon.
J Virol. 2001 Nov;75(22):10709-20.

Sugden B, Leight ER.
EBV's plasmid replicon: an enigma in cis and trans.
Curr Top Microbiol Immunol. 2001;258:3-11.

Leight ER, Sugden B.
Establishment of an oriP replicon is dependent upon an infrequent, epigenetic event.
Mol Cell Biol. 2001 Jul;21(13):4149-61.

Kaykas A, Worringer K, Sugden B.
CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complex.
EMBO J. 2001 Jun 1;20(11):2641-54.

Sandberg ML, Kaykas A, Sugden B.
Latent membrane protein 1 of Epstein-Barr virus inhibits as well as stimulates gene expression.
J Virol. 2000 Oct;74(20):9755-61.

Kaykas A, Sugden B.
The amino-terminus and membrane-spanning domains of LMP-1 inhibit cell proliferation.
Oncogene. 2000 Mar 9;19(11):1400-10.

Leight ER, Sugden B.
EBNA-1: a protein pivotal to latent infection by Epstein-Barr virus.
Rev Med Virol. 2000 Mar-Apr;10(2):83-100. Review.