American Cancer Society Research Professorship

RP-00-127-01 (ACS)

1/1/05 to 12/31/09

This is a Research Professorship to provide flexible funds for cancer research.

Cancer Biology Training Grant

T32 CA09135 (NIH/NCI)

This grant supports the training of graduate students in the program of cancer biology.

EBV's Plasmid Replicon: Its Synthesis, Partitioning, and Maintenance of Tumors

R01 CA133027 (NIH/NCI)

4/23/08 to 01/13/13

The goals of this research are: to measure the synthesis and partitioning of genomic EBV; to dissect the mechanism of EBV's partitioning; and to characterize EBV's contributions to maintaining PTLDs and AIDS-related lymphomas.

Genetic Analyses of EBV's Immortalizing Genes

R01 CA070723 (NIH/NCI)

4/1/07 to 1/31/12

The goals of this research are: to examine LMP1's signaling in EBV-infected B-cells and epithelial cells; to elucidate the mechanism of transcriptional regulation by EBNA1 in these cells; and to elucidate mechanisms of function of EBV's miRNAs in these cells.

Molecular Biology and Genetics of Tumor Viruses;
Sugden subproject: Transformation of Human B-Lymphocytes by Epstein-Barr Virus

P01 CA022443 (NIH/NCI)

5/1/03 to 4/30/08

The goals of this research are: to characterize EBNA1 and oriP; to characterize alternative origins of DNA synthesis in EBV; to elucidate its mechanism of partitioning its DNA; and to extend these analyses to KSHV1. In addition, this grant supports our work to identify and characterize molecularly the contributions EBV makes to sustain its associated lymphomas.