Publications 1972-1999

Bloss T, Kaykas A, Sugden B.
Dissociation of patching by latent membrane protein-1 of Epstein-Barr virus from its stimulation of NF-kappaB activity.
J Gen Virol. 1999 Dec;80 ( Pt 12):3227-32.

Mackey D, Sugden B.
Applications of oriP plasmids and their mode of replication.
Methods Enzymol. 1999;306:308-28.

Mackey D, Sugden B.
The linking regions of EBNA1 are essential for its support of replication and transcription.
Mol Cell Biol. 1999 May;19(5):3349-59.

Aiyar A, Sugden B.
Fusions between Epstein-Barr viral nuclear antigen-1 of Epstein-Barr virus and the large T-antigen of simian virus 40 replicate their cognate origins.
J Biol Chem. 1998 Dec 4;273(49):33073-81.

Aiyar A, Tyree C, Sugden B.
The plasmid replicon of EBV consists of multiple cis-acting elements that facilitate DNA synthesis by the cell and a viral maintenance element.
EMBO J. 1998 Nov 2;17(21):6394-403.

Kirchmaier AL, Sugden B.
Rep*: a viral element that can partially replace the origin of plasmid DNA synthesis of Epstein-Barr virus.
J Virol. 1998 Jun;72(6):4657-66.

Mackey D, Sugden B.
Studies on the mechanism of DNA linking by Epstein-Barr virus nuclear antigen 1.
J Biol Chem. 1997 Nov 21;272(47):29873-9.

Sandberg M, Hammerschmidt W, Sugden B.
Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3.
J Virol. 1997 Jun;71(6):4649-56.

Kirchmaier AL, Sugden B.
Dominant-negative inhibitors of EBNA-1 of Epstein-Barr virus.
J Virol. 1997 Mar;71(3):1766-75.

Mackey D, Middleton T, Sugden B.
Multiple regions within EBNA1 can link DNAs.
J Virol. 1995 Oct;69(10):6199-208.

Mitchell T, Sugden B.
Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus.
J Virol. 1995 May;69(5):2968-76.

Gahn TA, Sugden B.
An EBNA-1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP gene.
J Virol. 1995 Apr;69(4):2633-6.

Kirchmaier AL, Sugden B.
Plasmid maintenance of derivatives of oriP of Epstein-Barr virus.
J Virol. 1995 Feb;69(2):1280-3.

Kempkes B, Pich D, Zeidler R, Sugden B, Hammerschmidt W.
Immortalization of human B lymphocytes by a plasmid containing 71 kilobase pairs of Epstein-Barr virus DNA.
J Virol. 1995 Jan;69(1):231-8.

Bloss TA, Sugden B.
Optimal lengths for DNAs encapsidated by Epstein-Barr virus.
J Virol. 1994 Dec;68(12):8217-22.

Middleton T, Sugden B.
Retention of plasmid DNA in mammalian cells is enhanced by binding of the Epstein-Barr virus replication protein EBNA1.
J Virol. 1994 Jun;68(6):4067-71.

Gahn TA, Sugden B.
Marked, transient inhibition of expression of the Epstein-Barr virus latent membrane protein gene in Burkitt's lymphoma cell lines by electroporation.
J Virol. 1993 Nov;67(11):6379-86.

Martin JM, Veis D, Korsmeyer SJ, Sugden B.
Latent membrane protein of Epstein-Barr virus induces cellular phenotypes independently of expression of Bcl-2.
J Virol. 1993 Sep;67(9):5269-78.

Sugden B.
How some retroviruses got their oncogenes.
Trends Biochem Sci. 1993 Jul;18(7):233-5.

Sugden B.
EBV's open sesame.
Trends Biochem Sci. 1992 Jul;17(7):239-40.

Middleton T, Sugden B.
A chimera of EBNA1 and the estrogen receptor activates transcription but not replication.
J Virol. 1992 Mar;66(3):1795-8.

Middleton T, Sugden B.
EBNA1 can link the enhancer element to the initiator element of the Epstein-Barr virus plasmid origin of DNA replication.
J Virol. 1992 Jan;66(1):489-95.

Martin J, Sugden B.
The latent membrane protein oncoprotein resembles growth factor receptors in the properties of its turnover.
Cell Growth Differ. 1991 Dec;2(12):653-600.

Su W, Middleton T, Sugden B, Echols H.
DNA looping between the origin of replication of Epstein-Barr virus and its enhancer site: stabilization of an origin complex with Epstein-Barr nuclear antigen 1.
Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10870-4.

Martin J, Sugden B.
Transformation by the oncogenic latent membrane protein correlates with its rapid turnover, membrane localization, and cytoskeletal association.
J Virol. 1991 Jun;65(6):3246-58.

Sugden B.
Herpes viruses: human transducing viruses.
Trends Biochem Sci. 1991 Feb;16(2):45-6.

Middleton T, Gahn TA, Martin JM, Sugden B.
Immortalizing genes of Epstein-Barr virus.
Adv Virus Res. 1991;40:19-55.

Sternas L, Middleton T, Sugden B.
The average number of molecules of Epstein-Barr nuclear antigen 1 per cell does not correlate with the average number of Epstein-Barr virus (EBV) DNA molecules per cell among different clones of EBV-immortalized cells.
J Virol. 1990 May;64(5):2407-10.

Hammerschmidt W, Sugden B.
DNA replication of herpesviruses during the lytic phase of their life-cycles.
Mol Biol Med. 1990 Feb;7(1):45-57.

Hammerschmidt W, Sugden B.
Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes.
Nature. 1989 Aug 3;340(6232):393-7.

Sugden B, Warren N.
A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA-1, a viral protein required for viral DNA replication during latent infection.
J Virol. 1989 Jun;63(6):2644-9.

Hammerschmidt W, Sugden B, Baichwal VR.
The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels.
J Virol. 1989 Jun;63(6):2469-75.

Sugden B.
Epstein-Barr virus. Synthesis for a complex role.
Nature. 1989 May 18;339(6221):179-80.

Sugden B.
An intricate route to immortality.
Cell. 1989 Apr 7;57(1):5-7.

Baichwal VR, Hammerschmidt W, Sugden B.
Characterization of the BNLF-1 oncogene of Epstein-Barr virus.
Curr Top Microbiol Immunol. 1989;144:233-9.

Baichwal VR, Sugden B.
The multiple membrane-spanning segments of the BNLF-1 oncogene from Epstein-Barr virus are required for transformation.
Oncogene. 1989 Jan;4(1):67-74.

Hammerschmidt W, Sugden B.
Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus.
Cell. 1988 Nov 4;55(3):427-33.

Baichwal VR, Sugden B.
Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus.
Oncogene. 1988 May;2(5):461-7.

Sugden B, Warren N.
Plasmid origin of replication of Epstein-Barr virus, oriP, does not limit replication in cis.
Mol Biol Med. 1988 Apr;5(2):85-94.

Baichwal VR, Sugden B.
Latency comes of age for herpesviruses.
Cell. 1988 Mar 25;52(6):787-9.

Baichwal VR, Sugden B.
Posttranslational processing of an Epstein-Barr virus-encoded membrane protein expressed in cells transformed by Epstein-Barr virus.
J Virol. 1987 Mar;61(3):866-75.

Mecsas J, Sugden B.
Replication of plasmids derived from bovine papilloma virus type 1 and Epstein-Barr virus in cells in culture.
Annu Rev Cell Biol. 1987;3:87-108.

Reisman D, Sugden B.
trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.
Mol Cell Biol. 1986 Nov;6(11):3838-46.

Reisman D, Yates J, Sugden B.
A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components.
Mol Cell Biol. 1985 Aug;5(8):1822-32.

Miller G, Sugden B.
An identification of a transforming region of Epstein-Barr viral DNA cannot be confirmed.
Virology. 1985 Jun;143(2):478-84.

Yates JL, Warren N, Sugden B.
Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells.
Nature. 1985 Feb 28-Mar 6;313(6005):812-5.

Sugden B, Marsh K, Yates J.
A vector that replicates as a plasmid and can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virus.
Mol Cell Biol. 1985 Feb;5(2):410-3.

Reisman D, Sugden B.
An EBNA-negative, EBV-genome-positive human lymphoblast cell line in which superinfecting EBV DNA is not maintained.
Virology. 1984 Aug;137(1):113-26.

Sugden B, Yates J, Mark W.
Transforming functions associated with Epstein-Barr virus.
J Invest Dermatol. 1984 Jul;83(1 Suppl):82s-87s.

Yates J, Warren N, Reisman D, Sugden B.
A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells.
Proc Natl Acad Sci U S A. 1984 Jun;81(12):3806-10.

Sugden B, Metzenberg S.
Characterization of an antigen whose cell surface expression is induced by infection with Epstein-Barr virus.
J Virol. 1983 Jun;46(3):800-7.

Mark W, Sugden B.
Transformation of lymphocytes by Epstein-Barr virus requires only one-fourth of the viral genome.
Virology. 1982 Oct 30;122(2):431-43.

Sugden B.
Epstein-Barr virus: a human pathogen inducing lymphoproliferation in vivo and in vitro.
Rev Infect Dis. 1982 Sep-Oct;4(5):1048-61.

Grunwald DJ, Dale B, Dudley J, Lamph W, Sugden B, Ozanne B, Risser R.
Loss of viral gene expression and retention of tumorigenicity by Abelson lymphoma cells.
J Virol. 1982 Jul;43(1):92-103.

Kintner C, Sugden B.
Identification of antigenic determinants unique to the surfaces of cells transformed by Epstein-Barr virus.
Nature. 1981 Dec 3;294(5840):458-60.

Buell GN, Reisman D, Kintner C, Crouse G, Sugden B.
Cloning overlapping DNA fragments from the B95-8 strain of Epstein-Barr virus reveals a site of homology to the internal repetition.
J Virol. 1981 Dec;40(3):977-82.

Kintner C, Sugden B.
Conservation and progressive methylation of Epstein-Barr viral DNA sequences in transformed cells.
J Virol. 1981 Apr;38(1):305-16.

Sugden B, Phelps M, Domoradzki J.
Epstein-Barr virus DNA is amplified in transformed lymphocytes.
J Virol. 1979 Sep;31(3):590-5.

Kintner CR, Sugden B.
The structure of the termini of the DNA of Epstein-Barr virus.
Cell. 1979 Jul;17(3):661-71.

Sugden B, Kintner CR, Mark W.
The molecular biology of lymphotropic herpesviruses.
Adv Cancer Res. 1979;30:239-78.

Sugden B.
Comparison of Epstein-Barr viral DNAs in Burkitt lymphoma biopsy cells and in cells clonally transformed in vitro.
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4651-5.

Sugden B, Mark W.
Clonal transformation of adult human leukocytes by Epstein-Barr virus.
J Virol. 1977 Sep;23(3):503-8.

Sugden B, Summers WC, Klein G.
Nucleic acid renaturation and restriction endonuclease cleavage analyses show that the DNAs of a transforming and a nontransforming strain of Epstein-Barr virus share approximately 90% of their nucleotide sequences.
J Virol. 1976 May;18(2):765-75.

Sugden B, De Troy B, Roberts RJ, Sambrook J.
Agarose slab-gel electrophoresis equipment.
Anal Biochem. 1975 Sep;68(1):36-46.

Sugden B.
Viral RNA in cells carrying Epstein-Barr virus.
IARC Sci Publ. 1975;(11 Pt 1):171-6.

Botchan M, Ozanne B, Sugden B, Sharp PA, Sambrook J.
Viral DNA in transformed cells. III. The amounts of different regions of the SV40 genome present in a line of transformed mouse cells.
Proc Natl Acad Sci U S A. 1974 Oct;71(10):4183-7.

Klein G, Sugden B, Leibold W, Menezes J.
Infection of EBV-genome-negative and -positive human lymphoblastoid cell lines with biologically different preparations of EBV.
Intervirology. 1974;3(4):232-44.

Sambrook J, Sugden B, Keller W, Sharp PA.
Transcription of simian virus 40. 3. Mapping of "early" and "late" species of RNA.
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3711-5.

Sharp PA, Sugden B, Sambrook J.
Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose--ethidium bromide electrophoresis.
Biochemistry. 1973 Jul 31;12(16):3055-63.

Sugden B, Keller W.
Mammalian deoxyribonucleic acid-dependent ribonucleic acid polymerases. I. Purification and properties of an -amanitin-sensitive ribonucleic acid polymerase and stimulatory factors from HeLa and KB cells.
J Biol Chem. 1973 Jun 10;248(11):3777-88.

Jackson AH, Sugden B.
Inhibition by -amanitin of simian virus 40-specific ribonucleic acid synthesis in nuclei of infected monkey cells.
J Virol. 1972 Nov;10(5):1086-9.